COMPOSITIONS AND METHODS FOR SELECTIVELY PRODUCING SIRNA

The disclosure provided herein provides compositions and methods for producing siRNA. Also disclosed are compositions and methods for modulating the production of siRNA. Also disclosed herein are compositions and methods of treating a disease in a subject comprising administering a Dicer enzyme comp...

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Bibliographische Detailangaben
Hauptverfasser:	WELKER, NOAH, C, BASS, BRENDA, L, ARUSCAVAGE, PHILLIP, JOSEPH, JR, MAITY, TUHIN, S
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure provided herein provides compositions and methods for producing siRNA. Also disclosed are compositions and methods for modulating the production of siRNA. Also disclosed herein are compositions and methods of treating a disease in a subject comprising administering a Dicer enzyme comprising a helicase domain or a mutated Dicer enzyme to a subject. Also disclosed herein are methods of screening for a candidate modulator that modulates siRNA production. Compositions et procédés pour produire des ARNsi. Des compositions et des procédés pour moduler la production d'ARNsi ainsi que des compositions et des méthodes pour traiter une maladie chez un sujet comprenant l'administration audit sujet d'une enzyme Dicer comprenant un domaine hélicase ou d'une enzyme Dicer mutée sont également décrits. Cette invention concerne également des procédés de criblage destinés à identifier un candidat-modulateur qui module la production d'ARNsi.