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The present invention relates to an improved process for preparing acid addition salts of sunitinib, in particular sunitinib (2S)-2-hydroxybutanedioate (I). The invention also relates to compositions comprising sunitinib acid addition salts such as sunitinib (2S)-2- hydroxybutanedioate (I) and to th...

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Bibliographische Detailangaben
Hauptverfasser: HUBLIKAR, MAHESH GORAKHNATH, GORE, VINAYAK GOVIND, PATKAR, LAXMIKANT NARAHARI, POKHARKAR, KIRAN SHIVAJI, BANSODE, PRAKASH VISHNU
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:The present invention relates to an improved process for preparing acid addition salts of sunitinib, in particular sunitinib (2S)-2-hydroxybutanedioate (I). The invention also relates to compositions comprising sunitinib acid addition salts such as sunitinib (2S)-2- hydroxybutanedioate (I) and to the use of said compositions in the treatment of disease. La présente invention concerne un procédé amélioré de préparation des sels d'addition acide du sunitinib, en particulier du (2S)-2-hydroxybutanedioate de sunitinib (I). La présente invention concerne également des compositions comprenant des sels d'addition acide du sunitinib comme le (2S)-2-hydroxybutanedioate (I) de sunitinib et l'emploi desdites compositions dans le traitement de pathologies.