ANTI-VIRAL TREATMENT AND ASSAY TO SCREEN FOR ANTI-VIRAL AGENT

The present disclosure relates to novel compounds of formulas (1) thorugh (19) and to a method for treating humans infected with a virus including various respiratory viruses such as members of the Paramyxoviridae family (respiratory syncytial virus (RSV), human metapneumovirus (HMPV), human parainf...

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Hauptverfasser:	WHITE, ELLIE, LUCILE, RASMUSSEN, LYNN, CHUNG, DONG, HONG, MADDOX, CLINTON, BOYKIN, PATHAK, ASHISH, K, ANANTHAN, SUBRAMANIAM, MADDRY, JOSEPH, A, JONSSON, COLLEEN, B, SEVERSON, BILL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to novel compounds of formulas (1) thorugh (19) and to a method for treating humans infected with a virus including various respiratory viruses such as members of the Paramyxoviridae family (respiratory syncytial virus (RSV), human metapneumovirus (HMPV), human parainfluenza virus (HPIV), measles virus, and mumps virus) with a compound of formulas (1) through (19). The present disclosure also relates to a cytopathic effect (CPE)-based assay that will assess virus-induced CPE for screening of compounds for treating viral diseases or inhibiting a virus. L'invention concerne de nouveaux composés répondant aux formules (1) à (19), et un procédé destiné à traiter des personnes infectées par un virus, notamment un virus parmi différents virus respiratoires tels que les membres de la famille des paramyxovirus (virus respiratoire syncytial (VRS), métapneumovirus humain (hMPV), virus parainfluenza humain (hPIV), virus de la rougeole, et virus des oreillons), avec un composé des formules (1) à (19). L'invention concerne également un dosage basé sur l'effet cytopathique (ECP) qui évalue l'ECP induit par un virus pour cribler des composés destinés à traiter des maladies virales ou à inhiber un virus.