PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL

The present invention provides an improved process for the preparation of candesartan and pharmaceutically acceptable salts and esters thereof for use in the treatment of hypertension and related diseases. Specifically, it refers to the deprotection of tetrazolyl -protecting group of candesartan or...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SANJEEVI, LAKSHMIPATHI V, ARORA, SANJEEV KUMAR, KUMAR, ASHOK, SINGH, KAPTAN, ALLADA, SURESH, SHIRSATH, KRISHNARAO TUKARAM
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for the preparation of candesartan and pharmaceutically acceptable salts and esters thereof for use in the treatment of hypertension and related diseases. Specifically, it refers to the deprotection of tetrazolyl -protecting group of candesartan or its derivative in the presence of iodine in one or more alcoholic solvents. L'invention concerne un procédé amélioré de préparation de candésartan et de sels et d'esters de celui-ci utilisés pour traiter l'hypertension et des maladies associées. L'invention concerne spécifiquement la déprotection du groupe trityle dans le candésartan cilétexil en présence d'iode et de solvants alcooliques.