PROCESS FOR PREPARING CLOPIDOGREL HYDROGENSULFATE FORM I

The present invention relates to a process for preparing clopidogrel hydrogensulfate Form I having a large particle size and containing 0.1% or less impurities, and clopidogrel hydrogensulfate Form I produced thereby. The process of the present invention allows a clopidogrel hydrogensulfate Form I t...

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Bibliographische Detailangaben
Hauptverfasser:	SUNG, SI-YOUNG, KIM, MOON-SUNG, KIM, YONG-JIK, RYU, KI-MOON, YOO, MOO-HI, CHOI, JUN-HO, SON, BYOUNG-HWA, LIM, HONG-GYU, CHA, DAE-WON
Format:	Patent
Sprache:	eng ; fre ; kor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for preparing clopidogrel hydrogensulfate Form I having a large particle size and containing 0.1% or less impurities, and clopidogrel hydrogensulfate Form I produced thereby. The process of the present invention allows a clopidogrel hydrogensulfate Form I to have a pharmaceutically useful particle size and an even spherical form, and to contain 0.1% or less of impurities. L'invention concerne un procédé de préparation d'hydrogénosulfate de clopidogrel Forme 1 ayant une grande taille de particules et contenant au plus 0,1% d'impuretés, ainsi que l'hydrogénosulfate de clopidogrel Forme 1 produit selon ce procédé. Le procédé de l'invention permet d'obtenir un hydrogénosulfate de clopidogrel Forme 1 qui a une taille de particules pharmaceutiquement utile et une forme sphérique régulière et qui contient au plus 0,1% d'impuretés.