PROCESS FOR PREPARING (S)-(-)-10-ACETOXY-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE AND ITS ESTERS THEREOF

PROCESS FOR PREPARING (S)-(-)-10-ACETOXY-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE AND ITS ESTERS THEREOF

Disclosed herein an enzymatic process for preparing (S)-(-)-10-acetoxy-10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine) and its esters thereof. Further, the invention provides novel intermediates of eslicarbazepine and isomers thereof, enabling high purity and yield of eslicarbaz...

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Bibliographische Detailangaben
Hauptverfasser: DATTA, DEBASHISH, HUSAIN, MOFAZZAL
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Disclosed herein an enzymatic process for preparing (S)-(-)-10-acetoxy-10,11- dihydro-5H-dibenz[b,f]azepine-5-carboxamide (eslicarbazepine) and its esters thereof. Further, the invention provides novel intermediates of eslicarbazepine and isomers thereof, enabling high purity and yield of eslicarbazepine. La présente invention concerne un procédé enzymatique de préparation de (s)-(-)-10-acétoxy-10,11-dihydro-5H-dibenz[b,f]azépine-5-carboxamide (eslicarbazépine) et ses esters. En outre, l'invention concerne de nouveaux intermédiaires d'eslicarbazépine et leurs isomères, permettant d'obtenir une pureté élevée et un rendement élevé d'eslicarbazépine.