2-PYRIDONE COMPOUNDS USED AS INHIBITORS OF NEUTROPHIL ELASTASE

The invention provides compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human...

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Bibliographische Detailangaben
Hauptverfasser:	BERGSTROM, LENA, KRISTINA, KRISTOFFERSSON, ANNA, LINDSJOE, MARTIN, ASHTON, MARK, SJOE, PETER, OLOF, MEIGH, JON, MURUGAN, ANDIAPPAN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, L, X and Y are as defined in the specification; together with processes and intermediates for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase. L'invention concerne des composés de formule (I) dans laquelle R1, R3, R4, R5, R6, R7, L, X et Y sont tels que définis dans la description ; ainsi que des procédés et intermédiaires pour la préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs de l'élastase de neutrophile humaine.