MONOCONJUGATED CHITOSANS AS DELIVERY AGENTS FOR SMALL INTERFERING NUCLEIC ACIDS

MONOCONJUGATED CHITOSANS AS DELIVERY AGENTS FOR SMALL INTERFERING NUCLEIC ACIDS

Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly( ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjuga...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YOUSO, PATRICK, D, MCMANUS, SAMUEL, P, KOZLOWSKI, ANTONI
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Conjugates are provided, an exemplary conjugating having a single water-soluble, non-peptidic polymer, such as a poly( ethylene oxide), attached to a chitosan. Complexes of small interfering nucleic acids formed with such conjugates as well as small interfering nucleic acids attached to such conjugates are also provided. Related methods, intermediates, and compositions are also provided. L'invention concerne des conjugués, un conjugué à titre d'exemple ayant un unique polymère non peptidique soluble dans l'eau tel qu'un poly(oxyde d'éthylène) attaché à un chitosan. L'invention concerne également des complexes de petits acides nucléiques interférents formés avec de tels conjugués ainsi que de petits acides nucléiques interférents attachés à de tels conjugués. L'invention concerne également des procédés, intermédiaires et compositions apparentés.