AN IMPROVED PROCESS FOR THE PREPARATION OF PURE PALIPERIDONE

The present invention relates to an improved process for the preparation of pure Paliperidone of formula (I). The present invention more specifically provides an improved process for the preparation of pure Paliperidone which may contain impurities in the acceptable level of pharmacopoeia requiremen...

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Bibliographische Detailangaben
Hauptverfasser:	PONNAPALLY, KONDALARAO, REGURI, BUCHI, REDDY, ARUNAGIRI, MUTHULINGAM, KASIYAPPAN GURUSAMY, SARAVANAKUMAR
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to an improved process for the preparation of pure Paliperidone of formula (I). The present invention more specifically provides an improved process for the preparation of pure Paliperidone which may contain impurities in the acceptable level of pharmacopoeia requirement specifically 3-{2-[4-(5-Fluoro-benzo[d]isoxazol-3-yl]-piperidin-1-yl]-ethyl}-2- methyl-7,8-dihydro-6H-pyrido[1,2-a]pyrimidine-4,9-dione of Formula (IV). La présente invention a pour objet un procédé amélioré pour la préparation de palipéridone pure de formule (I). La présente invention concerne plus spécifiquement un procédé amélioré pour la préparation de palipéridone pure qui peut contenir des impuretés au niveau acceptable de l'exigence de la pharmacopée, spécifiquement de la 3-{2-¢4-(5-fluoro-benzo ¢d! isoxazol-3-yle!-pipéridin-1-yle!-éthyle}-2- méthyl-7,8-dihydro-6H-pyrido ¢1,2-a! pyrimidine-4,9-dione de formule (IV).