AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

AZINONE-SUBSTITUTED AZEPINO[B]INDOLE AND PYRIDO-PYRROLO-AZEPINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF

Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention. La prés...

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Bibliographische Detailangaben
Hauptverfasser: FREEMAN, EMILY, ELIZABETH, GUZZO, PETER, R, SURMAN, MATTHEW, DAVID, GRABOWSKI, JAMES, FRANCIS, JR
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention. La présente invention concerne de nouveaux antagonistes de récepteur MCH-1. Ces composés sont utilisés dans le traitement de différents troubles, comprenant l'obésité, l'anxiété, la dépression, la stéatose hépatique non alcoolique, et des troubles psychiatriques. La présente invention concerne en outre des procédés de préparation de ces composés.