REGIOSELECTIVE SYNTHESIS OF LETROZOLE
The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to nove...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | The present invention relates to an improved process for the preparation of letrozole (I) and its pharmaceutically acceptable salts, to compositions comprising letrozole or a pharmaceutically acceptable salt thereof, and to uses of such compositions. In particular it relates to a process and to novel intermediates for preparing letrozole and its salts substantially free from regioisomeric impurities.
L'invention concerne un procédé amélioré de préparation de létrozole (I) et de sels pharmaceutiquement acceptables de ce composé, des compositions comprenant du létrozole ou un sel pharmaceutiquement acceptable de ce composé, et des applications de telles compositions. L'invention concerne en particulier un procédé et de nouveaux produits intermédiaires utiles dans la préparation de létrozole et de sels de ce composé, qui sont sensiblement exempts d'impuretés régio-isomères. |
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