O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF

The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, auto...

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Bibliographische Detailangaben
Hauptverfasser:	GROSS, BENJAMIN, J, WALKER, SUZANNE, KAHNE, LAZARUS, MICHAEL, BLOCK
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and methods for using the same in diabetes and complications thereof, neurodegenerative diseases, cancers, autoimmune diseases, and inflammatory diseases. La présente invention concerne des inhibiteurs de la O-GlcNac transférase. Lesdits inhibiteurs sont, en règle générale, des quinolinone-6-sulfamides. L'invention concerne également des compositions pharmaceutiques en contenant et des méthodes d'utilisation de celles-ci dans le cadre du traitement du diabète et de ses complications, des maladies neurodégénératives, des cancers, des maladies auto-immunes et des maladies inflammatoires.