COMPOUNDS

A compound of formula (I): or its salts or pharmaceutically acceptable derivatives thereof wherein; A represents a chemical moiety with the general formula (II): X is selected from a group consisting of CH2, C(=O), CH(R5), C(R5)(R6) or C(R5)(R6)CH2; R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl; R2 is selected from the group consisting of optionally substituted aryl or optionally substituted heteroaryl or NR7R8; R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl or nitrile; R4 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted sulfamoyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl; R5 and R6 for each occurrence is optionally substituted alkyl; R7 and R8 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; n = 1 or 2 is provided. Pharmaceutical compositions comprising the compounds are also provided. The compounds are useful in treating various conditions including arrhythmia. La présente invention a pour objet un composé de formule (I) ou ses sels ou leurs dérivés pharmaceutiquement acceptables, A représentant un groupement chimique ayant la formule générale (II) ; X étant choisi dans le groupe comprenant CH2, C(=O), CH(R5), C(R5)(R6) et C(R5)(R6)CH2 ; R1 étant choisi dans le groupe comprenant un arylalkyle facultativement substitué et un hétéroarylalkyle facultativement substitué ; R2 étant choisi dans le groupe comprenant un aryle facultativement substitué et un hétéroaryle facultativement substitué et NR7R8 ; R3 étant choisi dans le groupe comprenant l'hydrogène, un halogène, un hydroxyle, un alcoxy, un aryloxy, un alkyle facultativement substitué, un amino facultativement substitué, un aminosulfonyle facultativement substitué et un nitrile ; R4 étant choisi dans le groupe comprenant l'hydrogène, un alkyle facultativement substitué, un cycloalkyle facultativement substitué, un hétérocycloalkyle facultativement substitué, un acyle faculta