MUTANTS OF FRANCISELLA TULARENSIS AND USES THEREOF

The present invention relates to a mutant Francisella tularensis strain comprising an inactivated clpB gene and compositions comprising such mutant. Methods of producing the mutant are also described. The present invention also encompasses a method of conferring immunity against F. tularensis in a h...

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Bibliographische Detailangaben
Hauptverfasser:	CONLAN, JOSEPH WAYNE, SJOSTEDT, ANDERS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a mutant Francisella tularensis strain comprising an inactivated clpB gene and compositions comprising such mutant. Methods of producing the mutant are also described. The present invention also encompasses a method of conferring immunity against F. tularensis in a host, comprising administering the described mutant F. tularensis strain. La présente invention porte sur une souche mutante de Francisella tularensis comprenant un gène clpB inactivé et sur des compositions comprenant un tel mutant. L'invention porte également sur des procédés de production du mutant. La présente invention porte également sur un procédé consistant à conférer une immunité contre F. tularensis chez un hôte, comprenant l'administration de la souche mutante de F. tularensis décrite.