PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS
An improved process for the preparation of proton pump inhibitors, such as 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole and pharmaceutically acceptable salts thereof is disclosed. The process involves protecting lansoprazole sulphide with D (+)-camphor su...
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| creator | VENKATESH, MUMMADI SATYANARAYANA REDDY, MANNE ESWARAIAH, SAJJA |
| description | An improved process for the preparation of proton pump inhibitors, such as 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole and pharmaceutically acceptable salts thereof is disclosed. The process involves protecting lansoprazole sulphide with D (+)-camphor sulphonyl chloride, followed by stereo selective oxidation using meta-chloroperbenzoic acid to obtain the camphor sulphonyl protected sulfoxide derivative, and stereo dexlansoprazole with high enantiomeric excess is prepared through deprotection of the camphor sulphonyl protected sulfoxide derivative.
La présente invention porte sur des procédés nouveaux et améliorés permettant la préparation d'inhibiteurs de pompe à protons tels que le 2-[(R)-[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole et sur leurs sels pharmaceutiquement acceptables. |
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La présente invention porte sur des procédés nouveaux et améliorés permettant la préparation d'inhibiteurs de pompe à protons tels que le 2-[(R)-[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole et sur leurs sels pharmaceutiquement acceptables.</description><language>eng ; fre</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101104&DB=EPODOC&CC=WO&NR=2010095144A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101104&DB=EPODOC&CC=WO&NR=2010095144A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>VENKATESH, MUMMADI</creatorcontrib><creatorcontrib>SATYANARAYANA REDDY, MANNE</creatorcontrib><creatorcontrib>ESWARAIAH, SAJJA</creatorcontrib><title>PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS</title><description>An improved process for the preparation of proton pump inhibitors, such as 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole and pharmaceutically acceptable salts thereof is disclosed. The process involves protecting lansoprazole sulphide with D (+)-camphor sulphonyl chloride, followed by stereo selective oxidation using meta-chloroperbenzoic acid to obtain the camphor sulphonyl protected sulfoxide derivative, and stereo dexlansoprazole with high enantiomeric excess is prepared through deprotection of the camphor sulphonyl protected sulfoxide derivative.
La présente invention porte sur des procédés nouveaux et améliorés permettant la préparation d'inhibiteurs de pompe à protons tels que le 2-[(R)-[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole et sur leurs sels pharmaceutiquement acceptables.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAMCPJ3dg0OVnDzD1IICHINcAxyDPH091PwdwNy_UOArIBQ3wAFTz8PTyfPEP-gYB4G1rTEnOJUXijNzaDs5hri7KGbWpAfn1pckJicmpdaEh_ub2RgaGBgaWpoYuJobEycKgAOEie_</recordid><startdate>20101104</startdate><enddate>20101104</enddate><creator>VENKATESH, MUMMADI</creator><creator>SATYANARAYANA REDDY, MANNE</creator><creator>ESWARAIAH, SAJJA</creator><scope>EVB</scope></search><sort><creationdate>20101104</creationdate><title>PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS</title><author>VENKATESH, MUMMADI ; SATYANARAYANA REDDY, MANNE ; ESWARAIAH, SAJJA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010095144A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>VENKATESH, MUMMADI</creatorcontrib><creatorcontrib>SATYANARAYANA REDDY, MANNE</creatorcontrib><creatorcontrib>ESWARAIAH, SAJJA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>VENKATESH, MUMMADI</au><au>SATYANARAYANA REDDY, MANNE</au><au>ESWARAIAH, SAJJA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS</title><date>2010-11-04</date><risdate>2010</risdate><abstract>An improved process for the preparation of proton pump inhibitors, such as 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole and pharmaceutically acceptable salts thereof is disclosed. The process involves protecting lansoprazole sulphide with D (+)-camphor sulphonyl chloride, followed by stereo selective oxidation using meta-chloroperbenzoic acid to obtain the camphor sulphonyl protected sulfoxide derivative, and stereo dexlansoprazole with high enantiomeric excess is prepared through deprotection of the camphor sulphonyl protected sulfoxide derivative.
La présente invention porte sur des procédés nouveaux et améliorés permettant la préparation d'inhibiteurs de pompe à protons tels que le 2-[(R)-[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole et sur leurs sels pharmaceutiquement acceptables.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS |
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