PROCESS FOR PREPARATION OF PROTON PUMP INHIBITORS

An improved process for the preparation of proton pump inhibitors, such as 2-[(R)-[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole and pharmaceutically acceptable salts thereof is disclosed. The process involves protecting lansoprazole sulphide with D (+)-camphor sulphonyl chloride, followed by stereo selective oxidation using meta-chloroperbenzoic acid to obtain the camphor sulphonyl protected sulfoxide derivative, and stereo dexlansoprazole with high enantiomeric excess is prepared through deprotection of the camphor sulphonyl protected sulfoxide derivative. La présente invention porte sur des procédés nouveaux et améliorés permettant la préparation d'inhibiteurs de pompe à protons tels que le 2-[(R)-[[3-méthyl-4-(2,2,2-trifluoroéthoxy)-2-pyridinyl]méthyl]sulfinyl]-1H-benzimidazole et sur leurs sels pharmaceutiquement acceptables.