A PROCESS FOR THE PREPARATION OF TOLTERODINE TARTRATE

A PROCESS FOR THE PREPARATION OF TOLTERODINE TARTRATE

The present invention relates to provide a process for the preparation of (+)-(R)-Tolterodine-L-tartrate, comprises a step of aminating hydroxyl protected 3-(2-methoxy-5-methylphenyl)-3-phenyl propanol of formula (V) with diisopropylamine in the presence of water to obtain N, N-diisopropyl-3-(2-meth...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DESAI, SANJAY, SHAH, CHANKRAKANT CHUNILAL, PAREKH, VIRAL MAHESHBHAI, PONNAIAH, RAVI, PATEL, KALPESH SHANTIBHAI
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to provide a process for the preparation of (+)-(R)-Tolterodine-L-tartrate, comprises a step of aminating hydroxyl protected 3-(2-methoxy-5-methylphenyl)-3-phenyl propanol of formula (V) with diisopropylamine in the presence of water to obtain N, N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropyl amine of formula (VI). La présente invention concerne un procédé de préparation du L-tartrate de (+)-(R)-toltérodine, comprenant une étape d'amination de l'hydroxyle protégé du 3-(2-méthoxy-5-méthylphényl)-3-phényl-propanol de formule (V) avec la diisopropylamine en présence d'eau afin d'obtenir la N,N-diisopropyl-3-(2-méthoxy-5-méthylphényl)-3-phénylpropyl-amine de formule (VI).