IMPROVED PROCESS FOR PREPARING AN INTERMEDIATE OF SERTRALINE

The present invention provides an improved process for preparation of N-[4-(3,4- dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenylidene]methanamine (ketimine) comprising condensation of 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone (sertralone) with monomethyl amine gas in the presence of a...

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Bibliographische Detailangaben
Hauptverfasser:	KARNIK, PRAVIN, PANDIT, VILAS, VASANT, NAIK, RAJESH, SHAH, PRANAY, PAWAR, NITIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides an improved process for preparation of N-[4-(3,4- dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenylidene]methanamine (ketimine) comprising condensation of 4-(3,4-dichlorophenyl)-3,4-dihydro-1-(2H)-naphthalenone (sertralone) with monomethyl amine gas in the presence of a dehydrating agent and an aprotic solvent. La présente invention porte sur un procédé amélioré de préparation de N-[4-(3,4-dichlorophényl)-3,4-dihydro-1-(2H)-naphtalénylidène]méthanamine (kétimine) comprenant la condensation de [4-(3,4-dichlorophényl)-3,4-dihydro-1-(2H)-naphtalénone (sertralone) avec de la monométhyl amine gazeuse en présence d'un agent déshydratant et d'un solvant aprotique.