FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE

The invention relates to thiazole compounds of Formula (I) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	WANG, XIANGHONG, HAN, NIANHE, LIU, QINGYIAN, DAVIS, CARL D, ASHTON, KATE S, FOTSCH, CHRISTOPHER H, YUAN, CHESTER CHENGUANG, ZENG, QINGPING, ST. JEAN, JR., DAVID J, YAO, GUOMIN, BOURBEAU, MATTHEW P, REICHELT, ANDREAS, TADESSE, SEIFU, ALLEN, JOHN G, HONG, FANG-TSAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to thiazole compounds of Formula (I) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders. La présente invention concerne des thiazoles de Formule (I) et leurs compositions, pouvant être employés dans le traitement de pathologies faisant intervenir la protéine kinase B (PKB), les variables ayant les valeurs décrites dans la présente invention. La présente invention concerne également l'emploi thérapeutique de tels thiazoles et des compositions pharmaceutiques les incluant dans le traitement d'états pathologiques associés à une croissance cellulaire anormale, un cancer, l'inflammation et aux troubles métaboliques.