N-BIPHENYLACYL THIAZOLIDINE-2,4-DIONE DERIVATIVES, THEIR SYNTHESIS AND USES

N- Biphenylacyl - thiazolidine-2,4-dione derivatives of the general formula (I); where in, Z1 and Z2 represent H, or together forms a chemical bond; R1 represents H, alkoxy, nitro, halo, hydroxy, optionally substituted amino group, - O-(CH2)n-N(R7)(R8), -O-(CH2)n-R9, wherein n is 0 to 5, -COOH, -CN, linear or branched alkyl, substituted alkyl, cycloalkyl, -S-R11 alkyl thio, acyl, aroyl, substituted or unsubstituted heterocyclic, alkoxy carbonyl, aryloxy, aryloxy carbonyl; R2 represents H, halo, hydroxy, linear or branched alkyl, substituted alkyl; R3, R4, R5 independently represents H, alkoxy, hydroxy, linear or branched alkyl, substituted alkyl; R6 represents H, -COOH, linear or branched alkyl, -CN, -SO3H, optionally substituted amino group; R7 represents H, linear or branched alkyl, cyclo alkyl, acyl, aroyl, aralkyl where in aryl moiety is substituted or unsubstituted, or an aryl; R8 represents a substituted or unsubstituted heterocyclic, linear or branched alkyl, substituted alkyl; R9 represents a substituted or unsubstituted heterocyclic, substituted or unsubstituted aromatic, substituted or unsubstituted cycloalkyl, fused arylheterocyclyl; when R1 represents alkoxy group, and Z1 and Z2 together forms a chemical bond then, R2 or R3 or R4 or R5 is other than H, and when R1, R2, R3, R4, R5 are each independently represents H, and Z1 and Z2 together forms a chemical bond then R6 is not H; And when R1, R2, R3, R4, R5 represents independently or together halo group and - Z1 and Z2 together forms a chemical bond, then R6 is not H; are novel compounds, their isomers and their enantiomers and their pharmaceutically acceptable salts or solvates and their pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicines and process for preparing the same. L'invention concerne des dérivés de N-biphénylacyl thiazolidine-2,4-dione de formule générale (I) dans laquelle Z1 et Z2 représentent un atome H ou forment ensemble une liaison chimique; R1 représente un atome H, un groupe alcoxy, nitro, halogéno, hydroxy, une groupe aminé éventuellement substitué, un groupe -O-(CH2)n-N(R7)(R8), -O-(CH2)n-R9, dans lesquels n vaut de 0 à 5, un groupe -COOH, -CN, alkyle linéaire ou ramifié, alkyle substitué, cycloalkyle, -S-R11 thio-alkyle, acyle, aroyle, hétérocyclique substitué ou non substitué, alcoxy-carbonyle, aryloxy, aryloxy-carbonyle; R2 représente un atome H, un groupe halogéno, hydroxy, alkyle linéaire ou ramifié, alkyle s