PREPARATION OF 3-(2-HYDROXY ETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO-[1,2-A]-PYRIMIDIN-4-ONE OR ITS ACID ADDITION SALT

PREPARATION OF 3-(2-HYDROXY ETHYL)-9-HYDROXY-2-METHYL-4H-PYRIDO-[1,2-A]-PYRIMIDIN-4-ONE OR ITS ACID ADDITION SALT

The invention relates to an improved process for preparation of 3-(2-hydroxy ethyl)-9- hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one or its acid addition salt and its conversion to paliperidone or its acid addition salt without involving the use of an acid catalyst. La présente invention concerne...

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Bibliographische Detailangaben
Hauptverfasser: BAPAT, UDAY, RAJARAM, SHARMA, ARUN, OMPRAKASH, MALIK, VINEET, JAIN, SUDHIR, HUKAMCHAND, PARIKH, SANJAY, NATVARLAL, KHAMAR, BAKULESH, MAFATLAL, DESAI, BHARAT, RAMCHANDRA, SODAGAR, KEVAL, RAMESHCHANDRA
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to an improved process for preparation of 3-(2-hydroxy ethyl)-9- hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one or its acid addition salt and its conversion to paliperidone or its acid addition salt without involving the use of an acid catalyst. La présente invention concerne un procédé amélioré de synthèse de la 3-(2-hydroxyéthyl)-9-hydroxy-2-méthyl-4H-pyrido[1,2-a]pyrimidin-4-one ou de son sel d'addition acide et sa conversion en palipéridone ou en son sel d'addition acide sans impliquer de catalyseur acide.