DRUG DELIVERY SYSTEM FOR ZERO ORDER, ZERO ORDER BIPHASIC, ASCENDING OR DESCENDING DRUG DELIVERY OF METHYLPHENIDATE

The invention is directed to a drag delivery device for controlled release of a drug, such as methylphenidate hydrochloride. The drug deliver device has a drug core, having a plug embedded therein, and at least a first coating that at least partially surrounds the core. The plug may be hollow or sol...

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Bibliographische Detailangaben
Hauptverfasser:	BRUCHIM, ANAT, BEISER, TEHILA, AQUA, OFER, ROSENBERGER, VERED
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The invention is directed to a drag delivery device for controlled release of a drug, such as methylphenidate hydrochloride. The drug deliver device has a drug core, having a plug embedded therein, and at least a first coating that at least partially surrounds the core. The plug may be hollow or solid, and swells upon absorption of water, bursting through the first coating. The drug delivery device enables zero-order drug release profiles as well as more complicated release profiles to be obtained. Cette invention concerne un dispositif d'administration médicamenteuse utilisé pour la libération contrôlée d'un médicament, tel que le chlorhydrate de méthylphénidate. Le dispositif d'administration médicamenteuse comporte un noyau de médicament doté d'un bouchon incorporé, et au moins un premier enrobage qui entoure au moins partiellement le noyau. Le bouchon peut être creux ou plein, il gonfle après absorption d'eau et éclate en traversant le premier enrobage. Le dispositif d'administration médicamenteuse permet d'obtenir des profils de libération médicamenteuse d'ordre zéro ainsi que des profils de libération plus complexes.