INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES
The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively high yield suitable for use on an industrial...
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| creator | GILL, HARPAL S LEE, GEORGE E POWERS, MATTHEW R WEIBERTH, FRANZ J ZHANG, JIUQING PLETTENBURG, OLIVER ROSSEN, KAI GESSLER, SIMON YU, YONG PODESCHWA, MICHAEL VANASSE, BENOIT J SHRIMP, II, FREDERICK L SUBOTKOWSKI, WITOLD WEHLAN, HERMUT A |
| description | The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively high yield suitable for use on an industrial scale. The present invention is also directed to synthetic intermediates that are useful for the preparation of (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxymethyl-2-[4-(4-methoxy- benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]-tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof.
La présente invention porte sur des procédés pour la production de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci, de pureté élevée et avec un rendement de production relativement élevé appropriés pour être utilisés à une échelle industrielle. La présente invention porte également sur des intermédiaires de synthèse qui sont utiles pour la préparation de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci. |
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La présente invention porte sur des procédés pour la production de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci, de pureté élevée et avec un rendement de production relativement élevé appropriés pour être utilisés à une échelle industrielle. La présente invention porte également sur des intermédiaires de synthèse qui sont utiles pour la préparation de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci.</description><language>eng ; fre</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100708&DB=EPODOC&CC=WO&NR=2010077623A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100708&DB=EPODOC&CC=WO&NR=2010077623A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GILL, HARPAL S</creatorcontrib><creatorcontrib>LEE, GEORGE E</creatorcontrib><creatorcontrib>POWERS, MATTHEW R</creatorcontrib><creatorcontrib>WEIBERTH, FRANZ J</creatorcontrib><creatorcontrib>ZHANG, JIUQING</creatorcontrib><creatorcontrib>PLETTENBURG, OLIVER</creatorcontrib><creatorcontrib>ROSSEN, KAI</creatorcontrib><creatorcontrib>GESSLER, SIMON</creatorcontrib><creatorcontrib>YU, YONG</creatorcontrib><creatorcontrib>PODESCHWA, MICHAEL</creatorcontrib><creatorcontrib>VANASSE, BENOIT J</creatorcontrib><creatorcontrib>SHRIMP, II, FREDERICK L</creatorcontrib><creatorcontrib>SUBOTKOWSKI, WITOLD</creatorcontrib><creatorcontrib>WEHLAN, HERMUT A</creatorcontrib><title>INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES</title><description>The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively high yield suitable for use on an industrial scale. The present invention is also directed to synthetic intermediates that are useful for the preparation of (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxymethyl-2-[4-(4-methoxy- benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]-tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof.
La présente invention porte sur des procédés pour la production de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci, de pureté élevée et avec un rendement de production relativement élevé appropriés pour être utilisés à une échelle industrielle. La présente invention porte également sur des intermédiaires de synthèse qui sont utiles pour la préparation de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPDz9AtxDfJ1dfF0DHENVnD0c1EICPJ3dg0OBvLc_IMUQjxcgSKuAY5BjiGe_n4K_m4Kbj6h_kH-7j6Rzv7Bni6uCi6uQZ5hQNkw12AeBta0xJziVF4ozc2g7OYa4uyhm1qQH59aXJCYnJqXWhIf7m9kYGhgYG5uZmTsaGhMnCoABGQv1w</recordid><startdate>20100708</startdate><enddate>20100708</enddate><creator>GILL, HARPAL S</creator><creator>LEE, GEORGE E</creator><creator>POWERS, MATTHEW R</creator><creator>WEIBERTH, FRANZ J</creator><creator>ZHANG, JIUQING</creator><creator>PLETTENBURG, OLIVER</creator><creator>ROSSEN, KAI</creator><creator>GESSLER, SIMON</creator><creator>YU, YONG</creator><creator>PODESCHWA, MICHAEL</creator><creator>VANASSE, BENOIT J</creator><creator>SHRIMP, II, FREDERICK L</creator><creator>SUBOTKOWSKI, WITOLD</creator><creator>WEHLAN, HERMUT A</creator><scope>EVB</scope></search><sort><creationdate>20100708</creationdate><title>INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES</title><author>GILL, HARPAL S ; LEE, GEORGE E ; POWERS, MATTHEW R ; WEIBERTH, FRANZ J ; ZHANG, JIUQING ; PLETTENBURG, OLIVER ; ROSSEN, KAI ; GESSLER, SIMON ; YU, YONG ; PODESCHWA, MICHAEL ; VANASSE, BENOIT J ; SHRIMP, II, FREDERICK L ; SUBOTKOWSKI, WITOLD ; WEHLAN, HERMUT A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2010077623A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2010</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>GILL, HARPAL S</creatorcontrib><creatorcontrib>LEE, GEORGE E</creatorcontrib><creatorcontrib>POWERS, MATTHEW R</creatorcontrib><creatorcontrib>WEIBERTH, FRANZ J</creatorcontrib><creatorcontrib>ZHANG, JIUQING</creatorcontrib><creatorcontrib>PLETTENBURG, OLIVER</creatorcontrib><creatorcontrib>ROSSEN, KAI</creatorcontrib><creatorcontrib>GESSLER, SIMON</creatorcontrib><creatorcontrib>YU, YONG</creatorcontrib><creatorcontrib>PODESCHWA, MICHAEL</creatorcontrib><creatorcontrib>VANASSE, BENOIT J</creatorcontrib><creatorcontrib>SHRIMP, II, FREDERICK L</creatorcontrib><creatorcontrib>SUBOTKOWSKI, WITOLD</creatorcontrib><creatorcontrib>WEHLAN, HERMUT A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GILL, HARPAL S</au><au>LEE, GEORGE E</au><au>POWERS, MATTHEW R</au><au>WEIBERTH, FRANZ J</au><au>ZHANG, JIUQING</au><au>PLETTENBURG, OLIVER</au><au>ROSSEN, KAI</au><au>GESSLER, SIMON</au><au>YU, YONG</au><au>PODESCHWA, MICHAEL</au><au>VANASSE, BENOIT J</au><au>SHRIMP, II, FREDERICK L</au><au>SUBOTKOWSKI, WITOLD</au><au>WEHLAN, HERMUT A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES</title><date>2010-07-08</date><risdate>2010</risdate><abstract>The present invention provides processes for producing (2S,3R,4R,5S,6R)-5-fluoro-6- hydroxymethyl-2-[4-(4-methoxy-benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]- tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof, of high purity and in a relatively high yield suitable for use on an industrial scale. The present invention is also directed to synthetic intermediates that are useful for the preparation of (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxymethyl-2-[4-(4-methoxy- benzyl)-5-trifluoromethyl-1H-pyrazol-3-yloxy]-tetrahydro-pyran-3,4-diol or a tautomer or hydrate thereof.
La présente invention porte sur des procédés pour la production de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci, de pureté élevée et avec un rendement de production relativement élevé appropriés pour être utilisés à une échelle industrielle. La présente invention porte également sur des intermédiaires de synthèse qui sont utiles pour la préparation de (2S,3R,4R,5S,6R)-5-fluoro-6-hydroxyméthyl-2-[4-(4-méthoxybenzyl)-5-trifluorométhyl-1H-pyrazol-3-yloxy]tétrahydropyran-3,4-diol ou d'un tautomère ou un hydrate de celui-ci.</abstract><oa>free_for_read</oa></addata></record> |
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| title | INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF FLUOROGLYCOSIDE DERIVATIVES |
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