POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS

POLYPEPTIDES AND POLYNUCLEOTIDES, AND USES THEREOF AS A DRUG TARGET FOR PRODUCING DRUGS AND BIOLOGICS

This invention relates to a novel target for production of immune and non¬ immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer...

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Bibliographische Detailangaben
Hauptverfasser: COHEN-DAYAG, ANAT, DASSA, LIAT, TOPORIK, AMIR, NEMZAR, SERGEY, SAMEACH-GREENWALD, SHIRLEY, MONTIA, EVE, ROTMAN, GALIT, ROSENBERG, AVI YESHAH, WALACH, SHIRA, LEVY, OFER, LEVINE, ZURIT, KINAR, YARON, BEIMAN, MERAV
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:This invention relates to a novel target for production of immune and non¬ immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTC AP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof. La présente invention concerne une nouvelle cible pour la production d'agents thérapeutiques à base immunitaire et non immunitaire et pour des diagnostics de maladie. Plus particulièrement, l'invention concerne des anticorps thérapeutiques contre les antigènes KRTCAP3, FAM26F, MGC52498, FAM70A ou TMEM154, qui sont exprimés de manière différentielle dans le cancer, et des utilisations diagnostiques et thérapeutiques. Cette invention concerne en outre des domaines extracellulaires des protéines KRTCAP3, FAM26F, MGC52498, FAM70A et TMEM154 et des variants, et des utilisations thérapeutiques de ceux-ci.