METHODS OF ANALYZING A-I RNA EDITING AND NUCLEIC ACID CONSTRUCTS CAPABLE OF SAME

A nucleic acid construct is disclosed. The nucleic acid construct comprises a first nucleic acid sequence encoding a detectable expression product, and a second nucleic acid sequence being capable of regulating expression of the detectable expression product in an ADAR (adenosine deaminase acting on...

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Bibliographische Detailangaben
Hauptverfasser:	RECHAVI, GIDEON, AMARIGLIO, NINETTE, BARBASH, ZOHAR S, SAFRAN, MICHAL
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A nucleic acid construct is disclosed. The nucleic acid construct comprises a first nucleic acid sequence encoding a detectable expression product, and a second nucleic acid sequence being capable of regulating expression of the detectable expression product in an ADAR (adenosine deaminase acting on RNA) -sensitive fashion. Cells and transgenic animals comprising same are also disclosed. Uses of the nucleic acid constructs are also disclosed. La présente invention concerne une construction d'acide nucléique. La construction d'acide nucléique comprend une première séquence d'acide nucléique codant pour un produit d'expression détectable, et une seconde séquence d'acide nucléique capable de réguler l'expression du produit d'expression détectable de manière sensible à ADAR (adénosine désaminase active sur l'ARN). La présente invention concerne également des cellules et des animaux transgéniques comprenant ceux-ci. La présente invention concerne en outre des utilisations des constructions d'acide nucléique.