TOLL-LIKE RECEPTOR AGONIST FORMULATIONS AND THEIR USE

The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonis...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	HOWBERT, J., JEFFRY, HERSHBERG, ROB, DUVVURI, MURALIKRISHNA, DIETSCH, GREG
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed generally to stable formulations of a TLR agonist preferably a TLR7 or a TLR8 agonist, for use in the treatment of cancer, preferably solid tumors and lymphomas. Specifically, the present invention is directed to stable formulations of up to 50 mg/ml of a TLR agonist which comprise a cyclodextrin. La présente invention porte d'une manière générale sur des formulations stables d'un agoniste de TLR, de préférence, un agoniste de TLR7 ou de TLR8, pour une utilisation dans le traitement du cancer, de préférence, de tumeurs solides et de lymphômes. La présente invention porte spécifiquement sur des formulations stables allant jusqu'à 50 mg/ml d'un agoniste de TLR qui comprend une cyclodextrine.