NILOTINIB INTERMEDIATES AND PREPARATION THEREOF

NILOTINIB INTERMEDIATES AND PREPARATION THEREOF

Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl- 5 -(4-methyl- 1 H-imidazole- 1 -yl)-benzeneamine; 3 -(4-(pyridin-3 -yl)pyrimidin-2-ylamino)-4- methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidi...

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Bibliographische Detailangaben
Hauptverfasser: HE, XUNGUI, KANSAL, VINOD, KUMAR, ZHU, JIRANG, ARIYAMUTHU, SUNDARASELVAN, LI, JIE, PILARSKI, GIDEON, MISTRY, DHIRENKUMAR, N, VASOYA, SANJAY, L, LIFSHITZ-LIRON, REVITAL, WANG, YANLING
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Intermediates of Nilotinib were prepared, including, for example, 3-(trifluoromethyl- 5 -(4-methyl- 1 H-imidazole- 1 -yl)-benzeneamine; 3 -(4-(pyridin-3 -yl)pyrimidin-2-ylamino)-4- methylbenzoyl halogen dihydrochloride; and N-(3-Bromo-5-trifluoromethylphenyl)-4- methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Nilotinib»3HCl and its crystalline forms are also described. L'invention concerne la préparation des intermédiaires de nilotinib, comprenant par exemple de la 3-(trifluorométhyl-5-(4-méthyl-1H-imidazole-1-yl)-benzèneamine ; du 3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-méthylbenzoyl-halogène-dihydrochlorure ; et du N-(3-bromo-5-trifluorométhylphényl)-4-méthyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. Du nilotinib 3HCl et ses formes cristallines sont également décrits.