A PROCESS FOR PREPARING HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES

A PROCESS FOR PREPARING HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES

The present invention relates to an improved process for synthesizing calcium salt of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid (Rosuvastatin Calcium) in high purity. L'invention concerne un procédé amélioré de syn...

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Bibliographische Detailangaben
Hauptverfasser: RUPAPARA, MAHESH, L, PATEL, DHIMANT, JASUBHAI, HOLKAR, ANIL, GANPAT, DWIVEDI, SHRIPRAKASH, DHAR, PATEL, MAYUR, R
Format: Patent
Sprache:eng ; fre
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to an improved process for synthesizing calcium salt of (E)-7-[4-(4-flurophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid (Rosuvastatin Calcium) in high purity. L'invention concerne un procédé amélioré de synthèse de sel de calcium d'acide (E)-7-[4-(4-flurophényl)-6-isopropyl-2-[méthyl(méthylsulfonyl)amino] pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-hepténoïque (calcium de rosuvastatine) de pureté élevée.