INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF
There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids an...
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| creator | BOMHOLT, NIELS BJERREGAARD PEDERSEN, ERIK MOSTAFA AHMED OSMAN, AMANY TROLLE JORGENSEN, PER |
| description | There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
L'invention se rapporte à un oligonucléotide d'intercalation pour stabiliser des triplex et des duplex d'ADN et d'ARN naturel ou modifié ainsi que leurs hybrides de structure générale (I). Les oligonucléotides formant triplex de l'invention peuvent se fixer spécifiquement à des acides nucléiques double brin cibles et sont par conséquent intéressants pour moduler l'activité des acides nucléiques cibles et aussi pour détecter les acides nucléiques cibles. |
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L'invention se rapporte à un oligonucléotide d'intercalation pour stabiliser des triplex et des duplex d'ADN et d'ARN naturel ou modifié ainsi que leurs hybrides de structure générale (I). Les oligonucléotides formant triplex de l'invention peuvent se fixer spécifiquement à des acides nucléiques double brin cibles et sont par conséquent intéressants pour moduler l'activité des acides nucléiques cibles et aussi pour détecter les acides nucléiques cibles.</description><language>eng ; fre</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091112&DB=EPODOC&CC=WO&NR=2009135890A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25566,76549</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091112&DB=EPODOC&CC=WO&NR=2009135890A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOMHOLT, NIELS</creatorcontrib><creatorcontrib>BJERREGAARD PEDERSEN, ERIK</creatorcontrib><creatorcontrib>MOSTAFA AHMED OSMAN, AMANY</creatorcontrib><creatorcontrib>TROLLE JORGENSEN, PER</creatorcontrib><title>INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF</title><description>There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
L'invention se rapporte à un oligonucléotide d'intercalation pour stabiliser des triplex et des duplex d'ADN et d'ARN naturel ou modifié ainsi que leurs hybrides de structure générale (I). Les oligonucléotides formant triplex de l'invention peuvent se fixer spécifiquement à des acides nucléiques double brin cibles et sont par conséquent intéressants pour moduler l'activité des acides nucléiques cibles et aussi pour détecter les acides nucléiques cibles.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEj39AtxDXJ29HEM8fRzVwgJ8gzwcY1wDVZw9HNRcAmFckKDQZKOQZE-Cn6OAR4hHv6evp4ujlH-PmB1AUH-zq7BwQpu_kEKIR6uQL5rgGMQ0ER_PxA_yNXfjYeBNS0xpziVF0pzMyi7uYY4e-imFuTHpxYXJCan5qWWxIf7GxkYWBoam1pYGjgaGhOnCgAJTza_</recordid><startdate>20091112</startdate><enddate>20091112</enddate><creator>BOMHOLT, NIELS</creator><creator>BJERREGAARD PEDERSEN, ERIK</creator><creator>MOSTAFA AHMED OSMAN, AMANY</creator><creator>TROLLE JORGENSEN, PER</creator><scope>EVB</scope></search><sort><creationdate>20091112</creationdate><title>INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF</title><author>BOMHOLT, NIELS ; BJERREGAARD PEDERSEN, ERIK ; MOSTAFA AHMED OSMAN, AMANY ; TROLLE JORGENSEN, PER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_WO2009135890A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre</language><creationdate>2009</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BOMHOLT, NIELS</creatorcontrib><creatorcontrib>BJERREGAARD PEDERSEN, ERIK</creatorcontrib><creatorcontrib>MOSTAFA AHMED OSMAN, AMANY</creatorcontrib><creatorcontrib>TROLLE JORGENSEN, PER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOMHOLT, NIELS</au><au>BJERREGAARD PEDERSEN, ERIK</au><au>MOSTAFA AHMED OSMAN, AMANY</au><au>TROLLE JORGENSEN, PER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF</title><date>2009-11-12</date><risdate>2009</risdate><abstract>There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
L'invention se rapporte à un oligonucléotide d'intercalation pour stabiliser des triplex et des duplex d'ADN et d'ARN naturel ou modifié ainsi que leurs hybrides de structure générale (I). Les oligonucléotides formant triplex de l'invention peuvent se fixer spécifiquement à des acides nucléiques double brin cibles et sont par conséquent intéressants pour moduler l'activité des acides nucléiques cibles et aussi pour détecter les acides nucléiques cibles.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF |
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