INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF

There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids an...

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Bibliographische Detailangaben
Hauptverfasser:	BOMHOLT, NIELS, BJERREGAARD PEDERSEN, ERIK, MOSTAFA AHMED OSMAN, AMANY, TROLLE JORGENSEN, PER
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids. L'invention se rapporte à un oligonucléotide d'intercalation pour stabiliser des triplex et des duplex d'ADN et d'ARN naturel ou modifié ainsi que leurs hybrides de structure générale (I). Les oligonucléotides formant triplex de l'invention peuvent se fixer spécifiquement à des acides nucléiques double brin cibles et sont par conséquent intéressants pour moduler l'activité des acides nucléiques cibles et aussi pour détecter les acides nucléiques cibles.