PROCESS FOR PREPARATION OF NARATRIPTAN HYDROCHLORIDE

The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SATHE, DHANANJAY, GOVIND, BHISE, NANDU, BABAN, PATNEKAR, SUBODH, SHASHIKANT, DEORE, RAVIRAJ, BHATU
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to an improved process for the preparation of N-methyl-3- (1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide hydrochloride of formula (I) having less than 0.15 % area by HPLC of 3-(1-methyl-4-piperidinyl)-1H-indole-5- ethanesulfonamide (1A) and intermediates thereof. La présente invention concerne un procédé amélioré permettant de préparer du N-méthyl-3- (1-méthyl-4-pipéridinyl)-1H-indole-5-éthanesulfonamide chlorhydrate représenté par la formule (I) comprenant moins de 0,15% en surface par HPLC de 3-(1-méthyl-4-pipéridinyl)-1H-indole-5- éthanesulfonamide (1A) et des produits intermédiaires de celui-ci.