NOVEL HETEROCYCLIC COMPOUNDS AND USES THEROF

New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase m...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH, AARON, XU, YONGJIN, ZHANG, QIONG, JIN, JEFF, MACHAJEWSKI, TIMOTHY, D, SHAFER, CYNTHIA, M, RENHOWE, PAUL, A, SENDZIK, MARTIN, POON, DANIEL, ANTONIOS-MCCREA, WILLIAM, R, MCKENNA, MAUREEN, HUANG, ZILIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	New substituted heterocyclic compounds, compositions containing them, and methods of using them for the inhibition of Raf kinase activity are provided. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer. La présente invention concerne de nouveaux composés hétérocycliques substitués, des compositions les contenant et leurs procédés d'utilisation dans le cadre de l'inhibition de l'activité de la Raf kinase. Les nouveaux composés et compositions peuvent être utilisés soit seuls, soit en combinaison avec au moins un agent supplémentaire afin de traiter un trouble induit par la Raf kinase, tel que le cancer.