O-ALKYLATED PI-3 KINASE INHIBITOR PRODRUG COMBINATION

The invention provides compounds, compositions, and therapeutic methods including methods for treating cancer by administering prodrugs of the PI-3 kinase inhibitor LY294002 alone or in combination with another treatment or anti-cancer agent. The inhibitor comprises a reversibly O-alkylated substitu...

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Bibliographische Detailangaben
Hauptverfasser:	DURDEN, DONALD, L, SU, JINGDON, PENG, XIAODONG, SUHR, ROBERT, G, GARLICH, JOSEPH, R, PATTERSON, MARY
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The invention provides compounds, compositions, and therapeutic methods including methods for treating cancer by administering prodrugs of the PI-3 kinase inhibitor LY294002 alone or in combination with another treatment or anti-cancer agent. The inhibitor comprises a reversibly O-alkylated substituent. Also provided is a composition comprising a combination of the prodrug PI-3 kinase inhibitor and an anti-cancer agent. L'invention porte sur des composés, des compositions et des procédés thérapeutiques, y compris des procédés de traitement du cancer, qui consistent à administrer des promédicaments de l'inhibiteur de PI-3 kinase LY294002 seul ou combiné à un autre traitement ou agent anticancéreux. L'inhibiteur précité comprend un substituant O-alkylé de façon réversible. L'invention concerne également une composition comprenant une combinaison du promédicament inhibiteur de PI-3 kinase et d'un agent anticancéreux.