PREPARATION OF ESOMEPRAZOLE MAGNESIUM AND HYDRATES THEREOF

The present invention includes processes for the preparation of crystalline esomeprazole magnesium dehydrate and/or trihydrate. The present invention includes esomeprazole magnesium dihydrate Form B having a degree of crystallinity of about 70% or less. The present invention includes micronized esom...

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Bibliographische Detailangaben
Hauptverfasser:	SEERAPU, SIVA PRASAD REDDY, KEDIA, UJJWAL, ELATI, RAVI RAM CHANDRASEKHAR, DEVARAKONDA, SURYA NARAYANA, YERRAGUNTLA, SESHA REDDY, BOLUGODDU, VIJAYA BHASKAR, CHEEMALAPATI, VENKATA ANNAPURNA SASIKALA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention includes processes for the preparation of crystalline esomeprazole magnesium dehydrate and/or trihydrate. The present invention includes esomeprazole magnesium dihydrate Form B having a degree of crystallinity of about 70% or less. The present invention includes micronized esomeprazole magnesium dihydrate Form B with a particle size distribution D90 equal to or less than about 10 µm. Cette invention concerne des procédés de préparation de magnésium d'ésoméprazole cristallisé dihydraté et/ou trihydraté. L'invention concerne la forme B d'ésoméprazole de magnésium dihydraté ayant un degré de cristallinité d'environ 70 % ou moins. L'invention concerne la forme B du magnésium d'ésoméprazole dihydraté micronisé d'une répartition granulométrique D90 égale ou inférieure à environ 10 µm.