CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF PROTEINS OF THE HSP70 FAMILY

A mutant protein of the Hsp70 family, which comprises the amino acid sequence from amino acid 1 to amino acid 380 that corresponds to an ATPase domain, wherein at positions 60 and 261 the amino acid residues have been mutated to cysteines, being all the positions defined from the initiation of the t...

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Hauptverfasser:	AYMAMI BOFARULL, JUAN, BONIN, IRENA, SOLER LOPEZ, MONTSERRAT, MARTINELL PEDEMONTE, MARC
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CALCULATING CHEMISTRY COMPOSITIONS THEREOF COMPUTING COUNTING CULTURE MEDIA ELECTRIC DIGITAL DATA PROCESSING ENZYMOLOGY GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	A mutant protein of the Hsp70 family, which comprises the amino acid sequence from amino acid 1 to amino acid 380 that corresponds to an ATPase domain, wherein at positions 60 and 261 the amino acid residues have been mutated to cysteines, being all the positions defined from the initiation of the translation of the protein. The invention also relates to a crystal of the mutant protein of the Hsp70 family, and to methods of identifying potential ligand compounds able to be further used in the preparation of medicaments for the treatment of cancer and some related diseases. La présente invention concerne une protéine mutante de la famille Hsp70 qui comprend la séquence d'acides aminés de l'acide aminé 1 à l'acide aminé 380 qui correspond à un domaine ATPase, dans laquelle aux positions 60 et 261, les résidus d'acides aminés ont été mutés en cystéines, étant toutes les positions définies à partir du début de la traduction de la protéine. L'invention concerne également un cristal de la protéine mutante de la famille Hsp70 et des procédés d'identification de composés ligands potentiels pouvant être en outre utilisés dans la préparation de médicaments destinés au traitement du cancer et de certaines maladies associées.