PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE

PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE

Disclosed herein is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt; comprising reacting carboxylic acid protected 11 - oxo - 6, 11 - Dihydrodibenz [b...

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Bibliographische Detailangaben
Hauptverfasser: VYAS KETAN DHANSUKHLAL, SHELKE YOGESH VISHWAS, PANANDIKAR, ADITI MILIND, NAIR RANJEET, CHAVAN RAJENDRA VASANTRAO
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Disclosed herein is a process for preparation of compound 11 - (Z) - [3 - (Dimethylamino) propylidene] - 6, 11 - dihydrodibenz [b, e] oxepin -2 - yl - acetic acid (Olopatadine) and its pharmaceutically acceptable salt; comprising reacting carboxylic acid protected 11 - oxo - 6, 11 - Dihydrodibenz [b, e] oxepin - 2 - acetic acid with 3 - dimethylaminopropyl triphenyl phosphonium halide in presence of a suitable base and an organic solvent. Cette invention concerne un procédé de préparation du composé acide 11-(Z)-[3-(diméthylamino)propylidène]-6,11-dihydrodibenz[b,e]oxépine-2-yl-acétique (olopatadine) et son sel pharmaceutiquement acceptable, comprenant la mise en réaction d'un acide carboxylique protégé acide 11-oxo-6,11-dihydrodibenz[b,e]oxépine-2-acétique avec un halogénure de 3-diméthylaminopropyl triphényl phosphonium en présence d'une base appropriée et d'un solvant organique.