RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF MCL-1

Oligonucleotides directed against the Mcl-1 gene are developed for modulating the expression of Mcl-1 protein. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding Mcl-1. Methods of using these compounds for modulation of Mcl-1 expre...

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Bibliographische Detailangaben
Hauptverfasser:	HANSEN, JENS BO, HOEG, ANJA MOELHART
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Oligonucleotides directed against the Mcl-1 gene are developed for modulating the expression of Mcl-1 protein. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding Mcl-1. Methods of using these compounds for modulation of Mcl-1 expression and for the treatment of diseases associated with over expression of Mcl-1 are provided. Examples of such diseases include cancer and systemic mastocytosis. On a mis au point des oligonucléotides dirigés contre le gène Mcl-1 afin de moduler l'expression de la protéine Mcl-1. Les compositions comprennent des oligonucléotides, notamment des oligonucléotides antisens, ciblés sur des acides nucléiques codant Mcl-1. Cette invention porte également sur des méthodes d'utilisation de ces composés en vue de moduler l'expression de Mcl-1 et pour le traitement de maladies associées à la surexpression de Mcl-1. Des exemples de ces maladies sont le cancer et la mastocytose généralisée.