IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NH...

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Bibliographische Detailangaben
Hauptverfasser:	ERICKSON, SCOTT A, FIDANZE, STEVE D, HUBBARD, ROBERT D, SARRIS, KATHY, CLARK, RICHARD F, BELL, RANDY L, BAMAUNG, NWE Y, MANTEI, ROBERT A, SORENSEN, BRYAN K, SHEPPARD, GEORGE S, WANG, GARY T, WANG, JIEYI
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1; La présente invention concerne des composés de formule I et leurs sels, promédicaments et sels de promédicaments , dans laquelle : X est CH ou N; A1 est R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, ou C(NH2)NOC(O)R1. Les composés selon l'invention sont inhibiteurs des protéines kinases. L'invention concerne également des compositions contenant les composés et des procédés de traitement de maladies mettant en oevre les composés.