THERAPEUTIC TARGETS AND MEDICAMENTS INVOLVING P230/GOLGIN-245

The present invention relates generally to the field of cell biology and in particular the cellular processes surrounding inflammation. Even more particularly, the present invention provides targets for medicaments useful in reducing levels of TNF-alpha, an extracellular pro-inflammatory mediator. T...

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Bibliographische Detailangaben
Hauptverfasser:	LOCK, JOHN, GEORGE, HAMMOND, LUKE, ALEXANDER, GLEESON, PAUL, ANTONY, STOW, JENNIFER, LEA, LIEU, ZI, ZHAO
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates generally to the field of cell biology and in particular the cellular processes surrounding inflammation. Even more particularly, the present invention provides targets for medicaments useful in reducing levels of TNF-alpha, an extracellular pro-inflammatory mediator. The medicaments are therefore useful in modulating inflammatory responses. Model inflammatory disease systems also form part of the present invention. La présente invention concerne d'une manière générale le domaine de la biologie cellulaire et, en particulier, les processus cellulaires entourant une inflammation. Encore plus particulièrement, la présente invention porte sur des cibles pour des médicaments utiles dans la réduction de taux de TNF-alpha, un médiateur pro-inflammatoire extracellulaire. Les médicaments sont par conséquent utiles dans la modulation des réponses inflammatoires. Des systèmes modèles de maladie inflammatoire font également partie de la présente invention.