TUNABLE AFFINITY LIGANDS FOR THE SEPARATION AND DETECTION OF TARGET SUBSTANCES

Conformationally tunable affinity ligands are rationally designed and selected for the ability to switch under operator-defined environmental conditions between or among structurally distinct states that have different affinities for a given target substance. Tunable affinity ligands are incorporate...

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Bibliographische Detailangaben
Hauptverfasser:	CUBICCIOTTI, ROGER, S, BRAUNLIN, WILLIAM, H, BEADLING, LESLIE, C
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE VINEGAR WINE
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Beschreibung
Zusammenfassung:	Conformationally tunable affinity ligands are rationally designed and selected for the ability to switch under operator-defined environmental conditions between or among structurally distinct states that have different affinities for a given target substance. Tunable affinity ligands are incorporated into reagents, separation media, assays, sensors, devices, kits and systems for sorting, separating, detecting, sensing, quantifying, identifying and monitoring target substances. Applications include biomedical research, diagnostics, drug discovery, bioproduction and processing and environmental, industrial, chemical, agricultural and military use. Des ligands à affinité conformationnellement accordable sont conçus et sélectionnés rationnellement pour leur capacité à permuter dans des conditions environnementales définies par l'opérateur entre des états structurellement distincts qui présentent des affinités différentes pour une substance cible donnée. Des ligands à affinités accordable sont incorporés dans des réactifs, des milieux de séparation, des dosages, des capteurs, des dispositifs, des kits et des systèmes permettant de trier, séparer, détecter, capter, quantifier, identifier et surveiller des substances cible. Des applications comprennent la recherche biomédicale, le diagnostic, la recherche de médicaments, la bioproduction, le conditionnement et des utilisations environnementales, industrielles, chimiques agricoles et militaires.