PEPTIDE VACCINE FOR INFLUENZA VIRUS
The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide e...
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| Format: | Patent |
| Sprache: | eng ; fre |
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| Zusammenfassung: | The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus, and to conjugates containing one or more such peptide epitopes. The peptide epitopes of the invention are cyclic peptides comprising a 7-mer peptide derived from H1, H3 or H5 hemagglutinin of influenza virus. The 7-mer peptide has a sequence corresponding to the loop sequence at positions 220- 226 of X31-hemagglutinin.
L'invention concerne des épitopes peptidiques destinés à être utilisés dans la prévention et/ou le traitement de la grippe ou dans le développement d'un tel traitement ou vaccin contre la grippe. Elle concerne également le procédé d'évaluation du potentiel de liaison d'une structure chimique, telle qu'un anticorps, à un épitope peptidique dérivé du site de liaison aux sialosides divalents de la protéine hémagglutinine du virus de la grippe. |
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