PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION

PYRIDAZINE DERIVATIVES FOR INHIBITING BETA AMYLOID PEPTIDE PRODUCTION

The present invention relates to novel compounds that inhibit the production of ß- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ß-amyloid levels or ß-amyloid deposits, particularly Alz...

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Bibliographische Detailangaben
Hauptverfasser: JOHNSON, MATTHEW, RUSSELL, LE, JOELLE, PRICE, HELEN, SUSANNE, EATHERTON, ANDREW, JOHN, GIBLIN, GERARD, MARTIN, PAUL, MYATT, JAMES, HALL, ADRIAN, MITCHELL, WILLIAM, LEONARD, NORTON, DAVID
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to novel compounds that inhibit the production of ß- amyloid peptide (1-42), processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated ß-amyloid levels or ß-amyloid deposits, particularly Alzheimer's disease. La présente invention concerne de nouveaux composés qui inhibent la production de peptide ß-amyloïde (1-42), des procédés pour leur préparation, des compositions les contenant et leur utilisation dans le traitement de maladies caractérisées par des niveaux élevés de ß-amyloïde ou des dépôts de ß-amyloïde, en particulier la maladie d'Alzheimer.