PROCESS FOR PREPARING 3-(2-(DIMETHYLAMINO)ETHYL)-N- METHYL-1H-INDOLE-5-METHANESULFONAMIDE AND PRODUCT THEREOF

The present invention relates to an improved process for the preparation of 3-(2- (dimethylamino) ethyl)-N-methyl- 1 H-indole-5-methanesulfonamide (sumatriptan) acid addition salt and the base having enhanced yield and purity. Further the present invention also provides a novel crystalline sumatript...

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Bibliographische Detailangaben
Hauptverfasser:	KOILKONDA, PURENDHAR, TYAGI, O., D, CHANDRADEV, R., V., N., VIKAS, MOUNESHWAR, A., V, SRIDHAR, R, SHARMA, JITENDRA, LAHIRI, SASWATA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention relates to an improved process for the preparation of 3-(2- (dimethylamino) ethyl)-N-methyl- 1 H-indole-5-methanesulfonamide (sumatriptan) acid addition salt and the base having enhanced yield and purity. Further the present invention also provides a novel crystalline sumatriptan base. La présente invention concerne un procédé amélioré pour la préparation du sel d'addition d'acide du 3-(2-(diméthylamino)éthyl)-N-méthyl-1H-indole-5-méthanesulfonamide (sumatriptan) et de la base avec un rendement et une pureté accrus. La présente invention concerne également une nouvelle forme cristalline de sumatriptan base.