COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT

COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT

Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof, which are effective in reducing the...

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Bibliographische Detailangaben
Hauptverfasser: EPPLER, CECIL, MARK, MUIR, WILLIAM, W., III, ZWIJNENBERG, RAPHAEL, JOHANNES, GERHARDUS, CULLEN, THOMAS, GERARD, HUSTEAD, DAVID, ROBERT
Format: Patent
Sprache:eng ; fre
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonic acid and derivatives thereof, which are effective in reducing the amount of anesthetic required to maintain anesthesia (i.e. to achieve an anesthetic-sparing effect). L'invention propose des compositions, des combinaisons et des procédés comportant des antagonistes de NMDA comprenant, mais sans s'y limiter, des antagonistes des récepteurs du glutamate NMDA tels que l'acide [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)-en-2-yl)alkyl]phosphonique et des dérivés de celui-ci, qui sont efficaces dans la réduction de la quantité d'anesthésique nécessaire pour maintenir l'anesthésie (à savoir, pour obtenir un effet d'épargne de l'anesthésique).