A PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE

A PROCESS FOR THE PREPARATION OF NARATRIPTAN HYDROCHLORIDE

The present invention provides a process for the preparation of Naratriptan hydrochloride which comprises decarboxylation of 5-{2-[(methylamino) sulfonyl] ethyl}-1H-indole-2-carboxylic acid to get 2-(1H-indol-5-yl)-N-methylethanesulfonamide using sulfolane as a solvent, and further reacting 2-(1H-in...

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Bibliographische Detailangaben
Hauptverfasser: SHARMA, HITESH, CHANDRAPRAKASH, SHANMUGA, SUNDARAM, BHARANI, KUMAR, SIRIPRAGADA, MAHENDER, RAO, UPPARAPALLI, SAMPATH, KUMAR, PANDIPRABU, MURUGESAN
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention provides a process for the preparation of Naratriptan hydrochloride which comprises decarboxylation of 5-{2-[(methylamino) sulfonyl] ethyl}-1H-indole-2-carboxylic acid to get 2-(1H-indol-5-yl)-N-methylethanesulfonamide using sulfolane as a solvent, and further reacting 2-(1H-indol-5-yl)-N-methylethanesulfonamide to obtain Naratriptan hydrochloride. La présente invention concerne un procédé de préparation de chlorhydrate de naratriptan, consistant à décarboxyler un acide 5-{2-[(méthylamino) sulfonyl] éthyl}-1H-indole-2-carboxylique de manière à obtenir du 2-(1H-indol-5-yl)-N-méthyléthanesulfonamide avec utilisation d'un sulfolane comme solvant, puis à faire réagir le 2-(1H-indol-5-yl)-N-méthyléthanesulfonamide de façon à obtenir du chlorhydrate de naratriptan.