RNA LIGASE POLYPEPTIDES AND METHODS OF SELECTION AND USE THEREOF

RNA LIGASE POLYPEPTIDES AND METHODS OF SELECTION AND USE THEREOF

The present invention features polypeptides capable of catalyzing a ligation reaction between a first RNA molecule comprising, e.g., a hydroxyl group at the 3' position and a second RNA molecule comprising, e.g., a triphosphate group at the 5' position. The invention further features metho...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SZOSTAK, JACK, W, CHO, GLEN, S, SEELIG, BURCHARD, KEEFE, ANTHONY, D
Format: Patent
Sprache:eng ; fre
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention features polypeptides capable of catalyzing a ligation reaction between a first RNA molecule comprising, e.g., a hydroxyl group at the 3' position and a second RNA molecule comprising, e.g., a triphosphate group at the 5' position. The invention further features methods of selecting, optimizing, and using such polypeptides. La présente invention concerne des polypeptides pouvant catalyser une réaction de ligature entre une première molécule d'ARN comprenant, par exemple, un groupe hydroxyle en position 3' et une seconde molécule d'ARN comprenant, par exemple, un groupe triphosphate en position 5'. L'invention concerne en outre des procédés de sélection, d'optimisation, et d'utilisation de ces polypeptides.