CRYSTALLINE ROTIGOTINE BASE AND PREPARATION PROCESS THEREFOR

An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used...

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Bibliographische Detailangaben
1. Verfasser:	KRIVONOS, SONIA
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	An isolated and pure crystalline rotigotine base of polymorph Form I, and processes for producing the crystalline rotigotine base are disclosed. Also disclosed is a transdermal patch for the delivery of rotigotine base using the disclosed isolated and pure form of rotigotine base, which can be used in treatment of Parkinson's Disease and other disorders ameliorated or treated by rotigotine, including restless leg syndrome L'invention concerne une base de rotigotine cristalline isolée et pure de Forme polymorphe I, et des procédés pour produire la base de rotigotine cristalline. L'invention concerne également un timbre transdermique pour l'administration de base de rotigotine à l'aide de la forme isolée et pure décrite de base de rotigotine, qui peut être utilisée dans le traitement de la maladie de Parkinson ou d'autres troubles améliorés ou traités par la rotigotine, comprenant le syndrome des jambes sans repos.