CARBOLINES AND THEIR USE AS IMAGING AGENTS

The invention relates to carbolines of formula (I) which are selective ligands for the GABAA receptor and which carry a radiolabel suitable for imaging with PET or SPECT or a radiolabel suitable for localisation of GABAA receptors in vitro. The compounds of the present invention are thus useful for...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	BOUVET, DENIS, RAYMOND, CHRISTOPHE, NEWINGTON, IAN, MARTIN
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to carbolines of formula (I) which are selective ligands for the GABAA receptor and which carry a radiolabel suitable for imaging with PET or SPECT or a radiolabel suitable for localisation of GABAA receptors in vitro. The compounds of the present invention are thus useful for in vitro diagnostics and in vivo imaging of the GABAA receptor. L'invention porte sur des carbolines de formule (I) qui sont des ligands sélectifs pour le récepteur GABAA et qui portent un radiomarqueur approprié pour l'imagerie avec PET ou SPECT ou un radiomarqueur approprié pour la localisation de récepteurs GABAA