METHOD FOR CONTROLLING GLUCOSE UPTAKE AND INSULIN SENSITIVITY

The invention provides methods for treating diabetes and related disorders, such as metabolic syndromes (which includes insulin resistance), by administering an inhibitor of osteopontin (OPN), which includes an antibody, antibody fragment, siRNA, and aptamer. Also disclosed are methods for increasin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SYARS, DOROTHY, MORTH, MICHAEL, ALDAN, CHAPMAN, JUSTIN, GUY, BINGHAM, JUSTIN, THOMAS
Format:	Patent
Sprache:	eng ; fre
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention provides methods for treating diabetes and related disorders, such as metabolic syndromes (which includes insulin resistance), by administering an inhibitor of osteopontin (OPN), which includes an antibody, antibody fragment, siRNA, and aptamer. Also disclosed are methods for increasing glucose uptake by cells in a subject, by administering an inhibitor of OPN. L'invention propose des procédés pour traiter le diabète et des troubles associés, tels que des syndromes métaboliques (qui comprennent la résistance à l'insuline), par l'administration d'un inhibiteur de l'ostéopontine (OPN) qui comprend un anticorps, un fragment d'anticorps, un ARNsi et un aptamère. Des procédés pour augmenter la prise de glucose par des cellules chez un sujet, par l'administration d'un inhibiteur d'OPN, sont également décrits.