RENIN INHIBITORS

Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protea...

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Hauptverfasser: KNAPP-REED, BETH, A, SEMUS, SIMON, ZHANG, JING, HOU, XIAOPING, DILLARD, LAWRENCE, W, TICE, COLIN, TRAN, TRITIN, YUAN, JING, GHIRLANDA, DAMIANO, SINGH, SURESH, B, ISHCHENKO, ALEXEY, V, CLAREMON, DAVID, MCGEEHAN, GERARD, XU, ZHENRONG, GHAVIMI-ALAGHA, BAHMAN, LU, QING, KALLANDER, LARA, S, FLAHERTY, PATRICK, T, SIMPSON, ROBERT, D, BALDWIN, JOHN, J, LAWHORN, BRIAN, TERRELL, LAMONT, R, ZHAO, WEI, CACATIAN, SALVACION
Format: Patent
Sprache:eng ; fre
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Zusammenfassung:Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof. L'invention concerne des composés qui se fixent aux protéases aspartiques pour inhiber leur activité. Ils sont utiles dans le traitement ou l'amélioration des symptômes de maladies associées à l'activité des protéases aspartiques. L'invention concerne également des méthodes d'utilisation des composés décrits dans la présente demande pour améliorer ou traiter les symptômes de troubles liés aux protéases aspartiques chez un sujet nécessitant un tel traitement.